MEMBRANE INTERACTIONS OF SMALL SOLUTES Studies with drugs and osmolytes
نویسندگان
چکیده
To Sanni 5 CONTENTS ABBREVIATIONS 8 LIST OF ORIGINAL PUBLICATIONS 10 SUMMARY 11 1. REVIEW OF THE LITERATURE 13 1.1. Biological membranes 13 Structure and composition 13 Dynamics and organization 13 1.2. Lipid dynamics 15 Intra-and intermolecular dynamics 15 Lateral pressure profile 16 Lipid bilayer as a permeability barrier 17 1.3. Membrane hydration 18 1.4. Membrane lateral heterogeneity 19 1.5. Lipid-protein interactions 21 1.6. Phase transitions 22 1.7. Drug-lipid interactions 24 Why to study drug-lipid interactions? 24
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